The nurse is caring for a patient with a fever and severe diarrhea in addition to thrombophlebitis. How will this patient's condition impact the clotting process?
A) Depleted production of Hageman factor
B) Increased production of thrombin
C) Activation of plasminogen
D) Reduced production of fibrinolysin
C
Feedback:
Plasminogen is the basis for the clot-dissolving system. It is converted to plasmin (fibrinolysin) by several factors including Hageman's factor, which is factor XII found in circulating blood. Activated thrombin breaks down fibrinogen to form fibrin threads, which form a clot inside the blood vessel. Patients with diarrhea or fever could alter the normal clotting process by, respectively, loss of vitamin K from the intestine or activation of plasminogen.
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