An infant has been diagnosed with a urinary tract infection. The nurse anticipates the health care provider may prescribe which medications as part of the treatment regimen?
Standard Text: Select all that apply.
1. Trimethoprim-sulfamethoxazole (TMP-SMZ)
2. Nitrofurantoin (Furadantin)
3. Fosfomycin (Monurol)
4. Norfloxacin (Noroxin)
5. Levofloxacin (Levaquin)
Correct Answer: 1,2
Rationale 1: Trimethoprim-sulfamethoxazole (TMP-SMZ) is a safe and effective treatment for infants with a urinary tract infection.
Rationale 2: Nitrofurantoin (Furadantin) is a safe and effective treatment for infants with a urinary tract infection.
Rationale 3: The safety and efficacy of fosfomycin (Monurol) have not been established in children younger than 12 years old.
Rationale 4: Norfloxacin (Noroxin) is a fluoroquinolone and as such is contraindicated for children under age 18 because these drugs have been found to affect cartilage development.
Rationale 5: Levofloxacin (Levaquin) is a fluoroquinolone and as such is contraindicated for children under age 18 because these drugs have been found to affect cartilage development.
Global Rationale: TMP-SMZ and nitrofurantoin are effective in children. However, fluoroquinolones are contraindicated in children under age 18 because these drugs have been found to affect cartilage development. The safety and efficacy of fosfomycin has not been established in children younger than 12 years old.
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