In the Jewish Chronic Disease Hospital Study, 22 patients were injected—unknowingly—with a suspension containing live cancer cells that had been generated from human cancer tissue. What ethical principles apply here? (Select all that apply.)
a. Beneficence
b. Self-determination
c. Anonymity
d. Confidentiality
e. Fair treatment
ANS: A, B, E
A highly publicized example of unethical research was a study conducted at the Jewish Chronic Disease Hospital in the 1960s. Its purpose was to determine the patients' rejection responses to live cancer cells. Twenty-two patients were injected with a suspension containing live cancer cells that had been generated from human cancer tissue. An extensive investigation of this study revealed the patients were not informed that they were taking part in research or that the injections they received were live cancer cells. In addition, the Jewish Chronic Disease Hospital Institutional Review Board never reviewed the study; even the physicians caring for the patients were unaware that the study was being conducted. In addition, the principle of beneficence requires the researcher to do good and "above all, do no harm."
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