Two nurses are discussing theories of drug-receptor interaction. One of the nurses states that which of the following statements is(are) true regarding the affinity of a drug and its receptor? (Select all that apply.)
a. Affinity and intrinsic activity are dependent properties.
b. Affinity refers to the strength of the attraction between a drug and its receptor.
c. Drugs with high affinity are strongly attracted to their receptors.
d. Drugs with low affinity are strongly attracted to their receptors.
e. The affinity of a drug for its receptors is reflected in its potency.
ANS: B, C, E
Affinity does refer to the strength of the attraction between a drug and its receptor, drugs with high affinity are strongly attracted to their receptors, and the affinity of a drug for its receptors is reflected in its potency.
Affinity and intrinsic activity are independent properties.
Drugs with low affinity are weakly attracted to their receptors.
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