To reinstate female sexual behavior in an ovariectomized rat, estradiol is given, followed by progesterone. How does estradiol prime sensitivity to progesterone?
A. Estradiol binds to progesterone receptors.
B. Estradiol promotes additional production of progesterone.
C. Estradiol does not impact the sensitivity to progesterone.
D. Estradiol increases production of progesterone receptors.
Answer: D
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