A patient is administered rifampin (Rifadin). Which of the following facts should the patient be taught?
A) When taking it with warfarin (Coumadin), an increased anticoagulant effect occurs.
B) It decreases hepatic enzymes and decreases metabolism of drugs.
C) It has an increased serum half-life, so it is more effective than rifabutin (Mycobutin).
D) The urine, tears, sweat, and other body fluids will be a discolored red-orange.
D
Feedback:
The patient's urine, tears, sweat, and other body fluids will be a discolored red-orange. This adverse effect is harmless, but the patient should be instructed on this adverse effect. The administration of this medication with warfarin will decrease the anticoagulant effect. The medication increases hepatic cytochrome P450 3A4 enzyme and decreases serum concentrations. The serum half-life of rifampin is shorter than that of the medication rifabutin.
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