A client has developed pericarditis following an episode of acute glomerulonephritis, developments that may be attributable to the presence of similar epitopes on group A beta-hemolytic streptococci and the antigens in the client's heart tissue
Which of the following has most likely accounted for this client's autoimmune response?
A) Breakdown of T-cell anergy
B) Release of sequestered antigens
C) Superantigens
D) Molecular mimicry
Ans: D
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Molecular mimicry is the phenomenon that exists when a microbe shares an immunologic epitope with the host, precipitating an autoimmune response. This miscategorization by cells of the immune system does not result from the release of sequestered antigens, failure of T-cell anergy, or the presence of superantigens.
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