The nurse is caring for a patient starting INH for latent tuberculosis. Which clinical manifestations would most concern the nurse?
a. Cramps in the back when walking up steps
b. Headaches and lightheadedness on awakening
c. Dry mouth and difficulty swallowing solids
d. Difficulty buttoning shirts
ANS: D
Difficulty buttoning shirts would most concern the nurse, because this may indicate neuropathy. Dose-related peripheral neuropathy is the most common adverse effect of INH therapy. The patient may experience numbness, burning, or tingling in the hands and feet.
Cramps in the back do not indicate neuropathy.
Headaches and lightheadedness on awakening are not associated with INH administration even over longer periods of time.
Dry mouth and difficulty swallow are not consistent with neuropathy.
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