Even though cancer genomes are overall hypomethylated, explain why some genes are hypermethylated in cancer cells

What will be an ideal response?


Hypermethylation of promoters will lead to reduced expression of those genes. Some genes such as cell cycle stop and DNA repair genes need to be expressed. When they aren't expressed, this can lead to cancer. Hypermethylation will reduce their expression.

Biology & Microbiology

You might also like to view...

We currently know:

A. all of the genetic risk factors for most cancers and many common diseases. B. many genetic risk factors for some cancers and common diseases. C. the individual mutations that cause colon cancer, breast cancer, and Alzheimer's disease. D. the individual mutations that cause breast cancer, lung cancer, and inflammatory bowel disease. E. the combination of genetic risk factors that cause skin cancer, lung cancer, and colon cancer.

Biology & Microbiology

Where does the Calvin cycle occur?

a. thylakoid membrane b. thylakoid lumen c. stromal lamellae

d. cytosol e. stroma

Biology & Microbiology

Steroid hormones are synthesized from _____

a. amines c. proteins b. peptides d. cholesterol

Biology & Microbiology

The external covering of the body is produced by

a. the ectoderm only. b. the endoderm only. c. the mesoderm only. d. the ectoderm and endoderm. e. all of the germ layers.

Biology & Microbiology