The nurse is to administer bumetanide. The nurse reviews the client's medication history for possible interacting drugs. Which of the following, if found, would the nurse identify as having an increased risk for toxicity? Select all that apply
A) Lithium
B) Phenytoin
C) Gentamicin
D) Warfarin
E) Digoxin
Ans: A, C, D, E
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Loop diuretics, like bumetanide, can increase toxicity of the following medications: lithium (Eskalith), gentamicin, warfarin (Coumadin), and digoxin (Lanoxin). A decrease in diuretic effect occurs when bumetanide is given with phenytoin.
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