Conditions that predispose to sickling of hemoglobin in persons with sickle cell anemia include:
A) Impaired red blood cell maturation
B) Increased iron content of blood
C) Decreased oxygen saturation
D) Increased intravascular volume
Ans: C
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Low oxygen in the tissues will cause red blood cells to take on the sickle shape in persons with sickle cell anemia. Sickle cell disease is a disorder of hemoglobin S and does not affect red blood cell maturation. The iron content is not affected by the sickling, but the capacity to carry the iron can be an effect of the affected RBCs. Dehydration can cause sickling by increasing the concentration of hemoglobin.
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