A client is diagnosed with liver disease. The nurse realizes that which element of pharmacokinetics will be affected in this client?
1. Absorption.
2. Distribution.
3. Biotransformation.
4. Excretion.
Correct Answer: 3
Rationale 1: Absorption is the process by which a drug passes into the bloodstream.
Rationale 2: Distribution is the transportation of a drug from its site of absorption to its site of action.
Rationale 3: Biotransformation, also called detoxification or metabolism, is a process by which a drug is converted to a less active form. Most biotransformation takes place in the liver. Biotransformation can be altered if a person has an unhealthy liver.
Rationale 4: Excretion is the process by which metabolites and drugs are eliminated from the body. Most drug metabolites are eliminated by the kidneys via the urine.
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