There can be interference with cancer chemotherapy in what phase of the cell cycle?
A) G0 phase
B) G1 phase
C) G2 phase
D) S phase
A
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During the G0 phase, the cell is stable. Cells in this phase can interfere with cancer chemotherapy because these drugs usually work on actively dividing cells, leaving resting cells mostly untouched. When the resting cells are stimulated to become active and regenerate, the cancer can return. This is the reason that cancer chemotherapy regimens are complicated and extended over a period of time. In the G1 phase, a cell is stimulated to emerge from its resting phase. During this time, the cell synthesizes the substances needed for DNA formation. The S phase involves the actual synthesis of DNA, and during the G2 phase, the cell produces all the substances that are required for the manufacture of the mitotic spindles.
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