Explain how cyclosporin A acts as an immunosuppressant drug
What will be an ideal response?
Cyclosporin A prevents the production of IL-2 and its high-affinity receptor, and thus prevents the activation of T cells and their proliferation and differentiation. It acts by inactivating the protein calcineurin. Calcineurin is a serine/threonine protein phosphatase that is activated by the first part of the T-cell receptor signaling pathway and dephosphorylates the transcription factor NFAT. This modification is necessary for NFAT, which normally resides in the cytoplasm, to enter the nucleus and stimulate transcription of the genes for IL-2 and the IL-2 receptor α chain. Inactivation of calcineurin by cyclosporin thus prevents the production of IL-2 and its high-affinity receptor.
You might also like to view...
A neuro exam checks all of the following except:
A) psychological functions. B) motor functions. C) sensory functions. D) mental status.
The drop in testosterone levels among men between the ages of 48 and 70 is sometimes called ____________________
Fill in the blank(s) with correct word
The attitude of passive alertness, signifying a lack of tension in allowing sensations to happen, is known as _____
a. mental focus b. unconscious thinking c. effortless effort d. thought stopping e. breath control
Lisa believes that smoking helps her manage her weight. What physiological reasons explain why smoking may contribute to weight loss or weight control?
What will be an ideal response?