When a client taking methotrexate notifies the nurse of a sudden onset of a rash, the nurse is alerted to what life-threatening adverse effect associated with methotrexate?
1. Peptic ulcer
2. Stevens–Johnson syndrome
3. Pancreatitis
4. Myocardial infarction
Correct Answer: 2
Rationale 1: This is potentially life-threatening, but not associated with a rash.
Rationale 2: This is the correct answer.
Rationale 3: This is potentially life-threatening, but not associated with a rash.
Rationale 4: This is life-threatening, but not associated with a rash.
Global Rationale: Severe, sometimes fatal, dermatologic reactions such as toxic epidermal necrolysis and SJS have been reported in those receiving methotrexate. The other conditions may be life-threatening, but are not associated with rash.
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