List and describe the two types of retinal bipolar cells and how they respond differently to the same neurotransmitter?
What will be an ideal response?
Light-on bipolar cells are inhibited in the dark (due to photoreceptor release of glutamate) and released from this
inhibition in the light. Light-off bipolar cells are the opposite. They are activated by the glutamate released in the dark and inhibited in the light. The difference between these cell types is the type of glutamate receptor. ON bipolar cells have metabotropic glutamate receptor (mGluR6) that hyperpolarize the cell in the dark when glutamate release is highest. OFF bipolar cells have an ionotropic glutamate receptors that open channels in the presence of glutamate to depolarize the cell.
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Fill in the blank(s) with correct word
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What will be an ideal response?