Why do Rh-negative but not Rh-positive mothers sometimes have babies with hemolytic disease of the newborn?
A.
This disease results when an Rh-negative mother's immune system is primed multiple times to produce anti-Rh IgG antibodies that can cross the placenta. If the mother is Rh-positive, she won't produce any anti-Rh antibodies at all.
B.
Rh-positive mothers produce IgM antibody, not IgG. This antibody can't cross the placenta, so it can't cause hemolytic disease of the newborn.
C.
Rh-positive mothers will receive a preventative shot from their physician prior to conception. This will provide the protection the fetus needs AFTER conception to avoid the disease.
D.
Rh-negativity is also associated with hyperproduction of antibodies. As such, Rh-negative mothers are more likely than Rh-positive mothers to produce the antibodies needed to produce this disease.
A
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