A patient takes antacids, cimetidine (Tagamet), and phenytoin (Dilantin). The health care provider prescribes a benzodiazepine for anxiety. Which drug interactions would the nurse anticipate? Select all that apply

a. Increased plasma level of benzodiazepine related to cimetidine therapy
b. Increased absorption of the benzodiazepine if taken with the antacid
c. Euphoria and disinhibition associated with phenytoin therapy
d. Serotonin syndrome associated with cimetidine use
e. Potential phenytoin toxicity


A, E
Cimetidine increases the plasma level of benzodiazepines. The benzodiazepine interferes with phenytoin metabolism, thus increasing serum levels of the anticonvulsants. The distracters do not reflect actual interactions.

Nursing

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