A nurse is teaching a group of nursing students about cyclooxygenase inhibitors. Which statement by a student indicates understanding of the teaching?
a. "Cyclooxygenase-2 inhibition causes gastrointestinal side effects."
b. "Cyclooxygenase-2 is considered the ‘bad COX.'"
c. "Inhibition of cyclooxygenase-1 promotes myocardial infarction and stroke."
d. "Inhibition of cyclooxygenase-1 results in suppression of inflammation."
ANS: B
Because cyclooxygenase-2 (COX-2) primarily mediates harmful processes in the body, it is called the "bad COX"; suppression of COX-2 results in largely beneficial effects. The gastrointestinal (GI) side effects of COX inhibitors are the result of COX-1 inhibition. One of two harmful side effects of COX-2 inhibition is suppression of vasodilation, which leads to an increased risk of myocardial infarction (MI) and stroke. Inhibition of COX-2 causes suppression of inflammation.
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