When Ron Evans generated transgenic mice in which the gene PPAR-delta was constitutively active (i.e., always expressed), he found that these mice showed a shift from fast glycolytic fibers to slow oxidative fibers. Based on this, faster sprint speeds in the transgenic mice would also be predicted.

Question

Answer the following statement true (T) or false (F)

Answer 1

False

Clarify Question

• What is the key concept addressed by the question?
   o The question asks about transgenic mice with a shift from glycolytic fibers to slow oxidative fibers.

• What type of thinking is required?
   o You are being asked to apply your knowledge transgenic mice with a shift from glycolytic fibers to slow oxidative fibers to predict their sprint speed.

Gather Content

• What do you know about glycolytic fibers and slow oxidative fibers? What other information is related to the question?
   o Slow-oxidative fibers have low rates of myosin ATPase activity but have the ability to make large amounts of ATP. These fibers are used for prolonged, regular types of movement, such as steady, long flight; long-distance swimming; or the maintenance of posture. Fast-glycolytic fibers have high myosin ATPase activity but cannot make as much ATP as oxidative fibers, because their source of ATP is glycolysis. These fibers are best suited for rapid, intense actions, such as a cheetah's short sprint at maximum speed.

Choose Answer

• Given what you now know, what information is most likely to produce the correct answer?
   o The correct answer is False. Slow oxidative fibers would be better for long endurance running while fast glycolytic fibers would be better for sprinting.

Reflect on Process

• Did your problem-solving process lead you to the correct answer? If not, where did the process break down or lead you astray? How can you revise your approach to produce a more desirable result?
   o This question asked you to apply your knowledge transgenic mice with a shift from glycolytic fibers to slow oxidative fibers to predict their sprint speed. If you got the correct answer, great job! If you got an incorrect answer, where did the process break down? Did you think that low oxidative fibers would be better for sprinting? Did you think that fast glycolytic fibers would be better for endurance running?