The student nurse is questioning the instructor about the different types of chemotherapeutic agents used to treat cancer. Which statement by the instructor best explains why lung cancers are less sensitive to antineoplastic agents than other types of can
A) "Lung cancer cells have a low growth fraction, so they are less sensitive to antineoplastic agents."
B) "Lung cancer cells grow in a high-oxygen environment, so they are not very sensitive to antineoplastic agents."
C) "Lung cancer cells have been growing for a long time before detection, so they are less sensitive to antineoplastic agents."
D) "Lung cancer cells have a very erratic cell cycle, so they are not very sensitive to antineoplastic agents."
Answer: A
Growth fraction is a ratio of the number of replicating cells to the number of resting cells. Antineoplastic drugs are much more toxic to tissues and tumors with high growth fractions. Breast and lung cancers have low growth fractions. Lung cancer cells may grow for a long time before detection, but this is not the primary reason they are less susceptible to antineoplastic agents. A high-oxygen environment is not the reason why lung cancer cells are less sensitive to antineoplastic agents. Lung cancer cells do not have a very erratic cell cycle.
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