What would be a primary advantage of using an attenuated agent rather than just an antigen from that agent for a vaccine?
A. This is actually a disadvantage-it's much more dangerous to use an attenuated agent over a subunit (single antigen) vaccine due to the possibility of reversion of the microbe to a pathogenic state.
B.
An attenuated agent strongly stimulates ONLY the antibody production (humoral response) of the adaptive immune system. This provides the best and strongest long-term protection.
C.
An attenuated agent strongly stimulates ONLY the cytotoxic T cell (CTL, cell-mediated) side of the adaptive immune system. This provides the best and strongest long-term protection.
D. An attenuated agent strongly stimulates both the humoral (antibody) AND cell-mediated (T cell) portions of the adaptive immune response, giving the best comprehensive long-term protection available.
D
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