Which of the following laboratory tests should be monitored in a patient receiving antitubercular drug therapy with rifampin (Rifadin)?
a. Liver function studies and hemoglobin level
b. Blood glucose, blood urea nitrogen (BUN), and platelet count
c. White blood cell (WBC) count and liver function studies
d. Complete blood count (CBC), liver enzymes, prothrombin time, and B12 and fo-late levels
ANS: D
Treatment with rifampin requires a CBC, liver enzymes, B12 and folate levels, and prothrombin time (PT) and international normalized ratio (INR) before and during therapy. Furthermore, PT and INR monitoring should be done more frequently because rifampin decreases the effective-ness of anticoagulants.
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