Which medication is used to increase red blood cell production in patients with renal failure?
1. Mannitol (Osmitrol)
2. Chlorthalidone (Hygroton)
3. Epoetin alfa (Epogen)
4. Methazolamide (Neptazane)
3
Rationale 1: Mannitol (Osmitrol) is an osmotic diuretic and does not increase RBC production.
Rationale 2: Chlorthalidone (Hygroton) is a thiazide-like diuretic and does not increase RBC production.
Rationale 3: Many patients with chronic renal failure will also have a deficiency of erythropoietin, a hormone secreted by the kidney. Erythropoietin serves as a primary signal to increase red blood cell production in the bone marrow. A synthetic form of erythropoietin, epoetin alfa (Epogen, Procrit), is effective in treating several disorders caused by a deficiency in red blood cells.
Rationale 4: Methazolamide (Neptazane) is a carbonic anhydrase inhibitor and does not increase RBC production.
Global Rationale: Many patients with chronic renal failure will also have a deficiency of erythropoietin, a hormone secreted by the kidney. Erythropoietin serves as a primary signal to increase red blood cell production in the bone marrow. A synthetic form of erythropoietin, epoetin alfa (Epogen, Procrit), is effective in treating several disorders caused by a deficiency in red blood cells. The other medications listed are not sure to increase red blood cell production.
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