Explain the importance of promiscuous binding specificity exhibited by MHC class I and class II molecules
What will be an ideal response?
Each MHC molecule can bind to a very large number of peptides made up of different sequences of amino acids. The consequence of this promiscuity is that humans need only encode a relatively small number of MHC molecules in their genome if they are to bind to the huge number of pathogen-derived peptides encountered during a lifetime of infections. Because MHC molecules are coexpressed on the cell surface, this also ensures that an appropriate density of MHC molecules populates the cell surface to ensure efficient T-cell engagement and subsequent activation.
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A) as self or non-self B) by function C) by the molecules on their cell surface D) by function and the kinds of molecules on their cell surface
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