Explain how hematopoiesis uses autocrine, paracrine, and juxtacrine signaling. Choose one and provide an example of signaling through that pathway
What will be an ideal response?
Answer: Autocrine signaling: produced by and act on the same cell. Example: Rarely seen; T-cells and IL-2.
Paracrine signaling: produced by and act on adjacent cells. Example: progenitors and precursors adjacent to the BM stroma.
Juxtacrine signaling: The cytokine remains membrane-bound, which requires interaction between membrane and membrane receptors to achieve the desired effect. Example: stem cells and SCF or FL.
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Fill in the blank(s) with the appropriate word(s).
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Fill in the blank(s) with the appropriate word(s).