Which statement should the nurse include in the teaching for a patient who is to be started on zileuton [Zyflo]?
A. "Use your zileuton [Zyflo] inhaler every 12 hours."
B. "Have your blood drawn once a month for the next 3 months so that your liver function can be checked."
C. "Take the zileuton [Zyflo] 2 hours before eating breakfast each day."
D. "Take an extra dose of zileuton [Zyflo] if you have an asthmatic attack."
Answer: B. "Have your blood drawn once a month for the next 3 months so that your liver function can be checked."
Explanation: Zileuton can injure the liver, as evidenced by increased plasma levels of alanine aminotransferase (ALT). Therefore, ALT should be monitored once a month for 3 months, then every 2 to 3 months for the remainder of the first year, and periodically thereafter. Zileuton is an oral, not an inhaled, medication that is rapidly absorbed with or without food. The timing of administration with regard to meals is insignificant. Zileuton is used for asthma prophylaxis and cannot be used to abort an attack.
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