An elderly resident of an assisted-living facility has had his mobility and independence significantly impaired by the progression of his rheumatoid arthritis (RA)
What is the primary pathophysiologic process that has contributed to this client's decline in health?
A) A mismatch between bone resorption and remodeling
B) Immunologically mediated joint inflammation
C) Excessive collagen production and deposition
D) Cytokine release following mechanical joint injury
Ans: B
Feedback:
The pathogenesis of RA can be viewed as an aberrant immune response that leads to synovial inflammation and destruction of the joint architecture. Paget disease is caused by abnormal bone resorption and remodeling, whereas collagen deposition underlies scleroderma. Osteoarthritis is believed to be initiated by mechanical injury and subsequent cytokine release.
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