Which statement made by a parent would indicate an understanding about the genetic transmission of cystic fibrosis (CF)?
a. "Only one parent carries the cystic fibrosis gene.".
b. "Both parents are carriers of the cystic fibrosis gene.".
c. "The presence of the disease is most likely the result of a genetic mutation.".
d. "The mother is usually the carrier of the cystic fibrosis gene.".
B
Cystic fibrosis follows a pattern of autosomal recessive transmission. Both parents must be carriers of the gene for the disease to be transmitted to the child. If both parents carry the CF gene, each pregnancy has a 25% chance of producing a CF-affected child. Cystic fibrosis will not be present if only one parent is a carrier of the cystic fibrosis gene and is known to have a definite pattern of transmission. It is transmitted as an autosomal recessive trait. A carrier parent can transmit the carrier gene to the child. The disease is present when the carrier gene is transmitted from both parents.
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