What is the maximum Lod score for linkage at this locus?

Linkage between a gene of interest and a DNA marker is being studied. A mating results in 19 parental and 1 recombinant offspring.

A) 0.22
B) 1.1
C) 6.3
D) 11


C) 6.3

Explanation: 1 individual out of 20 total are recombinant.

The denominator of the Lod score calculation is (1/2)20 = 9.53 × 10-7

The numerator of the Lod score uses the formula (1 - RFobs)#P × (RFobs)#R. Here, RFobs = 1/20, #P = 19, and #R = 1. Thus, the numerator is (19/20)19 × (1/20)1 = 1.89 × 10-2

The likelihood ratio is 1.89 × 10-2 / 9.53 × 10-7 = 1.98 × 106

The Lod score is log10(1.98 × 106) = 6.3

Biology & Microbiology

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