Immunoglobulin E (IgE)–mediated anaphylactic shock occurs as a result of
a. direct activation of mast cells.
b. laryngeal edema.
c. an antigen entering on a repeat exposure, triggering a secondary immune response.
d. the systemic inflammatory response.
C
IgE is an antibody that is formed as part of the immune response. The first time an antigen enters the body, an antibody IgE, specific for the antigen, is formed. The antigen-specific IgE antibody is then stored by attachment to mast cells and basophils. This initial contact with the antigen is known as a primary immune response. The next time the antigen enters the body, the preformed IgE antibody reacts with it, and a secondary immune response occurs.
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