On a specific chromosome, an enhancer helps activate the expression of Gene A, but not Gene B, which is equally close to the enhancer. A mutant is identified where this enhancer is now activating the expression of both Gene A and Gene B. Explain what has
likely been mutated.
What will be an ideal response?
Gene A is activated by the enhancer but not Gene B due to an insulator sequence that allows the enhancer to only activate Gene A and prevents activation of Gene B. However, in this mutant, the insulator is mutated and can no longer block the activation of Gene B by the enhancer and thus both Genes A and B are activated by this enhancer.
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