A client is diagnosed with metastatic prostate cancer. The client asks the nurse the purpose of his treatment with the luteinizing hormone-releasing hormone (LH-RH) agonist leuprolide (Lupron) and the bisphosphonate pamidronate (Aredia)
Which statement by the nurse is most appropriate?
a.
"The treatment reduces testosterone and prevents bone fractures."
b.
"The medications prevent erectile dysfunction and increase libido."
c.
"There is less gynecomastia and osteoporosis with this drug regimen."
d.
"These medications both inhibit tumor progression by blocking androgens."
ANS: A
Lupron, an LH-RH agonist, stimulates the pituitary gland to release luteinizing hormone (LH) to the point that the gland is depleted of LH and testosterone production is lessened. This may decrease the prostate cancer since it is hormone dependent. Lupron can cause osteoporosis, which results in the need for Aredia to prevent bone loss. Erectile dysfunction, decreased libido, and gynecomastia are side effects of the LH-RH medications. Antiandrogen drugs inhibit tumor progression by blocking androgens at the site of the prostate.
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