Which of the following diuretics maybe combined to work on different parts of the nephron?
a. Loop and thiazide diuretics
b. Loop and osmotic diuretics
c. Osmotic and carbonic anhydrase inhibitor diuretics
d. Thiazide and osmotic diuretics
A
A thiazide diuretic such as chlorothiazide (Diuril) or metolazone (Zaroxolyn) may be administered and followed by a loop diuretic to take advantage of the fact that these medications work on different parts of the nephron. Sometimes a thiazide diuretic is added to a loop diuretic to compensate for the development of loop diuretic resistance.
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