Which of the following is/are true of antibiotic usage and the development of antibiotic resistance?
A. Antibiotics select for resistant mutants and bacteria possessing R-plasmids, increasing their frequency in the population.
B. Antibiotics increase the rate of bacterial transformation, conjugation, and transduction, and thus increase the spread of antibiotic resistance.
C. Antibiotics cause mutations (antibiotics are mutagens), thus resulting in increasingly resistant bacterial populations.
D. Antibiotics cause R-plasmids to form and cause their transfer, spreading antibiotic resistance.
E. All of these choices are correct.
Answer: A
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