A diabetic client is controlled on Avandia (rosiglitazone), a thiazolidinedione medication that acts at the level of nuclear peroxisome proliferator-activated receptors (PPARs) to promote:

A) Glucose uptake
B) Stimulation of the beta cells in the pancreas
C) Increase in basal metabolic rate
D) Weight loss by shrinking fat cells


Ans: A
Feedback:
The thiazolidinedione medications, which are used in the treatment of type 2 diabetes mellitus, act at the level of nuclear PPAR-? receptors to promote glucose uptake and utilization by adipose tissue cells. These drugs do not increase release of insulin from the pancreas, increase BMR, or promote weight loss.

Health & Biomechanics

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