The following are important steps in the process of endochondral ossification
1. Blood vessels grow around the edges of the cartilage and perichondrium differentiates into osteoblasts.
2. Capillaries and osteoblasts migrate to the epithyses forming the secondary ossification centers.
3. Chondrocytes enlarge and the surrounding matrix begins to calcify.
4. Remodeling continues and the shaft becomes thicker.
5. Blood vessels penetrate the cartilage and invade the central region forming the primary ossification center.
What is the correct order for these events?
A) 3, 1, 5, 4, 2
B) 1, 3, 5, 4, 2
C) 1, 5, 3, 4, 2
D) 2, 3, 1, 5, 4
E) 3, 1, 4, 5, 2
Answer: A
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