A 74-year-old woman was diagnosed with rheumatoid arthritis 1 year ago, but has achieved adequate symptom control through the regular use of celecoxib (Celebrex), a COX-2 selective NSAID
The nurse should recognize that this drug, like other NSAIDs, influences what aspect of the pathophysiology of nociceptive pain?
A) Distorting the action potential that is transmitted along the A-delta (?) and C fibers
B) Diverting noxious information from passing through the dorsal root ganglia and synapses in the dorsal horn of the spinal cord
C) Blocking modulation by limiting the reuptake of serotonin and norepinephrine
D) Inhibiting transduction by blocking the formation of prostaglandins in the periphery
Ans: D
Feedback:
NSAIDs produce pain relief primarily by blocking the formation of prostaglandins in the periphery; this is a central component of the pathophysiology of transduction. NSAIDs do not act directly on the aspects of transmission, perception, or modulation of pain that are listed.
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