A client has a diagnosis of chronic renal failure secondary to diabetic nephropathy. Which of the following hematologic changes may result from this client's kidney disorder?
A) Anemia
B) Leukocytosis
C) Thrombocytopenia
D) Leukopenia
Ans: A
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Erythropoietin is a polypeptide hormone that regulates the differentiation of RBCs in the bone marrow. Between 89% and 95% of erythropoietin is formed in the kidneys. The synthesis of erythropoietin is stimulated by tissue hypoxia, which may be brought about by anemia, residence at high altitudes, or impaired oxygenation of tissues due to cardiac or pulmonary disease. Persons with chronic kidney disease often are anemic because of an inability of the kidneys to produce erythropoietin. Changes in platelet or white blood cell levels are not likely to result directly from renal failure.
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