What are the products of mast-cell activation?
What will be an ideal response?
Mast cells contain preformed granules containing a wide range of inflammatory mediators that are triggered to be released extracellularly through an exocytic mechanism called degranulation. The inflammatory mediators contained in the granules and released immediately include histamine, heparin, TNF-?, and proteases involved in the remodeling of connective tissue matrix. The proteases include tryptase and chymotryptase (expressed by mucosal and connective mast cells, respectively), cathepsin G, and carboxypeptidase. Additional inflammatory mediators are generated after mast-cell activation, including IL-3, IL-4, IL-5, IL-13, GM-CSF, CCL3, leukotrienes C4 and D4, and platelet-activating factor.
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