Which medication, when administered with lithium, increases the risk of toxicity?
1. Lomefloxacin
2. Sodium bicarbonate
3. Calcium iodine
4. Furosemide
Correct Answer: 4
Rationale 1: Lomefloxacin does not increase the risk of toxicity if taken with lithium.
Rationale 2: Sodium bicarbonate does not increase the risk of toxicity if taken with lithium.
Rationale 3: Calcium iodine does not increase the risk of toxicity if taken with lithium.
Rationale 4: Lithium, when combined with a diuretic such as furosemide, increases the potential for sodium depletion, thereby increasing therapeutic blood levels of lithium to the toxic range.
Global Rationale: Lithium, when combined with a diuretic such as furosemide, increases the potential for sodium depletion, thereby increasing therapeutic blood levels of lithium to the toxic range. Lomefloxacin, sodium bicarbonate, and calcium iodine do not increase the risk of toxicity if taken with lithium.
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