A client is being treated for cocaine and amphetamine abuse. The nurse realizes that the client's symptoms are caused by which actions of these substances on the central nervous system?
Standard Text: Select all that apply.
1. Stimulate the release of norepinephrine on the presynaptic neuron
2. Inhibit the reuptake of norepinephrine from the synaptic cleft back to the presynaptic neuron
3. Inhibit the destruction of norepinephrine by the enzyme monoamine oxidase
4. Inhibit alpha1 receptors
5. Stimulate beta2 receptors
Correct Answer: 1,2
Rationale 1: This is a mechanism of action of amphetamines.
Rationale 2: This is a mechanism of action for cocaine.
Rationale 3: This is not a mechanism of action for either cocaine or amphetamines.
Rationale 4: This is not a mechanism of action for either cocaine or amphetamines.
Rationale 5: This is not a mechanism of action for either cocaine or amphetamines.
Global Rationale: Stimulating the release of norepinephrine on the presynaptic neuron is the mechanism of action for amphetamines. Inhibiting the reuptake of norepinephrine from the synaptic cleft back to the presynaptic neuron is the mechanisms of action for cocaine. The other statements do not indicate a mechanism of action for either cocaine or amphetamines.
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