The ability of an organism to become unresponsive over time to an anti-infective is termed:
1. superinfection.
2. sensitivity.
3. mutation.
4. acquired resistance.
Correct Answer: 4
Rationale 1: A superinfection is a secondary infection that occurs when antibiotic therapy kills normal flora.
Rationale 2: Sensitivity is the ability of an organism to be killed or of its growth to be halted by an antibiotic.
Rationale 3: Mutation is the ability of an organism to adapt and change. This leads to antibiotic resistance.
Rationale 4: Acquired resistance is the ability of an organism to become insensitive to the effects of an anti-infective.
Global Rationale: Acquired resistance is the ability of an organism to become unresponsive over time to the effects of an anti-infective. Resistance can occur in bacteria, fungi, viruses, and protozoans. It is a major clinical problem that is growing in importance.
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