A client is scheduled to receive a diuretic and a beta blocker. The nurse determines the combination of these drugs will have which effect on the client's blood pressure?
1. Oppositional
2. Synergistic
3. Antagonistic
4. Additive
Correct Answer: 4
Rationale 1: The drugs have different actions, but they do not oppose each other.
Rationale 2: The two drugs together might not have a greater effect than the effects of each drug used separately.
Rationale 3: The two drugs will not antagonize or cancel the actions of each other.
Rationale 4: The two drugs together have an additive effect on blood pressure. The diuretic will reduce blood volume; the beta blocker will block vasoconstriction, causing a decrease in peripheral vascular resistance. These two different actions will both help to reduce blood pressure.
Global Rationale: The two drugs together have an additive effect on blood pressure. The diuretic will reduce blood volume; the beta blocker will block vasoconstriction, causing a decrease in peripheral vascular resistance. These two different actions will both help to reduce blood pressure. The drugs have different actions, but they do not oppose each other. The two drugs together might not have a greater effect than the effects of each drug used separately. The two drugs will not antagonize or cancel the actions of each other.
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