The client with morbid obesity asks the nurse why leptin is not used for weight reduction. Which response would be most appropriate for the nurse?
1. "Oral leptin would cause an increase in body mass index."
2. "Obese individuals develop a resistance to the effects of leptin."
3. "Leptin supplement is only effective in individuals with normal body weight."
4. "The amount of leptin required would potentiate nephrotoxicity."
Correct Answer: 2
Rationale 1: Leptin would cause a decrease in body mass index.
Rationale 2: Leptin is not used for weight loss, because obese individuals develop a resistance to the effects of this substance.
Rationale 3: Leptin is not given as a supplement and would not be necessary for an individual with normal weight.
Rationale 4: Leptin is a substance produced in the body and does not cause nephrotoxicity.
Global Rationale: Leptin is not used for weight loss, because obese individuals develop a resistance to the effects of this substance. It is not administered to those of normal weight and has no effect on nephrotoxicity. Leptin would cause a decrease in body mass.
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