A portion of a gene has the following DNA sequence: GAAGGAGTAGCA, which when translated gives the amino acid sequence leucine-proline-histidine-arginine. Assume a mutation causes a C to be inserted into the sequence in between the second A and the second

G. Predict how this would affect the protein produced when it is translated.

What will be an ideal response?


Each three bases is a codon, which codes for a specific amino acid. If a C is inserted into the sequence, the grouping of bases into codons would be completely different from that point on. The first codon would still be GAA, but the second codon would be changed from GGA to CGG, the codon after that would become AGT instead of GTA, and so on. This would completely change the amino acid sequence and would completely change the protein produced.

Biology & Microbiology

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