A client who takes avorstatin (Lipitor) daily has been prescribed erythromycin for sinusitis
To prevent consequences of an adverse effect of this combination of drugs, it is most important for the nurse to monitor this client for which clinical manifestation?
1. Lack of expected response to erythromycin.
2. New onset of muscle pain.
3. Abdominal pain and cramping.
4. Bleeding from the oral cavity and bruising.
Correct Answer: 2
Rationale 1: Avorstatin (Lipitor) does not decrease the therapeutic effect of erythromycin.
Rationale 2: Muscle pain may be a sign of rhabdomyolysis, which is a life-threatening condition. The risk of rhabdomyolysis is increased for clients taking a macrolide drug such as erythromycin, because macrolides significantly increase blood levels of avorstatin.
Rationale 3: Abdominal pain and cramping are experienced by some clients as a side effect of erythromycin, but this effect is not enhanced by the interaction with avorstatin (Lipitor).
Rationale 4: Coagulation is not altered as a consequence of the interaction of these two drugs.
Global Rationale: Muscle pain may be a sign of rhabdomyolysis, which is a life-threatening condition. The risk of rhabdomyolysis is increased for clients taking a macrolide drug such as erythromycin, because macrolides significantly increase blood levels of avorstatin. Avorstatin (Lipitor) does not decrease the therapeutic effect of erythromycin. Abdominal pain and cramping are experienced by some clients as a side effect of erythromycin, but this effect is not enhanced by the interaction with avorstatin (Lipitor). Coagulation is not altered as a consequence of the interaction of these two drugs.
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