A nurse is teaching her client about cyclosporine therapy following a recent liver transplant. What statement by the client indicates further teaching is needed?

Question

1. "I might experience a decrease in urinary flow."
2. "I can take acetaminophen (Tylenol) for a headache, but I have to be very careful."
3. "I can take this drug with any fluid as long as it is at the same time every day."
4. "I will need to come into the clinic for periodic blood counts."

Answer 1

Correct Answer: 3

Rationale 1: "I might experience a decrease in urinary flow" is incorrect because the primary adverse effect of cyclosporine occurs in the kidney, with up to 75 percent of clients experiencing reduction in urine flow.
Rationale 2: "I can take acetaminophen (Tylenol) for a headache, but I have to be very careful" is incorrect because while cyclosporine can damage the kidneys, other nephrotoxic drugs such as amphotericin B, NSAIDs, or aminoglycosides should be administered with great caution.
Rationale 3: The primary adverse effect of cyclosporine occurs in the kidney, with up to 75 percent of clients experiencing reduction in urine flow. Frequent laboratory tests of kidney function are necessary. Because cyclosporine can damage the kidneys, other nephrotoxic drugs such as amphotericin B, NSAIDs, or aminoglycosides should be administered with great caution.
Rationale 4: "I will need to come into the clinic for periodic blood counts" is incorrect because frequent laboratory tests of kidney function are necessary.

Global Rationale: The primary adverse effect of cyclosporine occurs in the kidney, with up to 75 percent of clients experiencing reduction in urine flow. Frequent laboratory tests of kidney function are necessary. Because cyclosporine can damage the kidneys, other nephrotoxic drugs such as amphotericin B, NSAIDs, or aminoglycosides should be administered with great caution. "I might experience a decrease in urinary flow" is incorrect because the primary adverse effect of cyclosporine occurs in the kidney, with up to 75 percent of clients experiencing reduction in urine flow. "I can take acetaminophen (Tylenol) for a headache, but I have to be very careful" is incorrect because while cyclosporine can damage the kidneys, other nephrotoxic drugs such as amphotericin B, NSAIDs, or aminoglycosides should be administered with great caution. "I will need to come into the clinic for periodic blood counts" is incorrect because frequent laboratory tests of kidney function are necessary.