Probenecid inhibits the active resorption of uric acid in the kidney, which leads to increased urinary excretion of uric acid. Explain why this drug would be useful in treating gout
What will be an ideal response
Uric acid, a normal waste product of nucleic acid metabolism, is ordinarily excreted in urine without any problem. However, when blood levels of uric acid rise excessively, it may be deposited as needle-shaped urate crystals in the soft tissue of joints. An inflammatory response follows, which leads to gout. By lowering the uric acid level, no crystals form, and inflammation subsides.
You might also like to view...
Where in the oral cavity are you most likely to observe veins close to the surface?
A. hard palate. B. marginal gingiva. C. mucobuccal fold. D. ventral surface of the tongue. E. the lingual tonsil.
What category of receptors do Pacinian corpuscles belong to?
A. Chemoreceptors B. Nociceptors C. Photoreceptors D. Mechanoreceptors
Which of the following will respond to a threshold stimulus with an all-or-none contraction?
A. a single muscle fiber B. a single motor unit C. a whole muscle D. a single muscle fiber and a single motor unit E. a single muscle fiber, a single motor unit, and a whole muscle
If extracellular fluid osmolality is 385 mOsm/kg, the kidneys will increase reabsorption of
A. urea. B. water. C. sodium. D. potassium. E. chloride.