Probenecid inhibits the active resorption of uric acid in the kidney, which leads to increased urinary excretion of uric acid. Explain why this drug would be useful in treating gout
What will be an ideal response
Uric acid, a normal waste product of nucleic acid metabolism, is ordinarily excreted in urine without any problem. However, when blood levels of uric acid rise excessively, it may be deposited as needle-shaped urate crystals in the soft tissue of joints. An inflammatory response follows, which leads to gout. By lowering the uric acid level, no crystals form, and inflammation subsides.
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