Which action is the most appropriate description for cholinesterase inhibitors?
1. Intensify transmission at neuromuscular junctions only.
2. Prevent transmission at neuromuscular junctions only.
3. Prevent transmission at muscarinic, ganglionic, and neuromuscular junctions.
4. Intensify transmission at muscarinic, ganglionic, and neuromuscular junctions.
Correct Answer: 4
Rationale 1: They prevent transmission at all sites.
Rationale 2: Cholinesterase inhibitors are used to reduce the action of cholinesterase, thereby making more acetylcholine available to nerve cells in the brain.
Rationale 3: They break apart the neurotransmitter acetylcholine, which is vital for the transmission of nerve impulses.
Rationale 4: They can act on all three sites.
Global Rationale: Cholinesterase inhibitors intensify transmission at muscarinic, ganglionic, and neuromuscular junctions. They prevent transmission at all sites, not just the neuromuscular junction. Cholinesterase inhibitors are used to reduce the action of cholinesterase, thereby making more acetylcholine available to nerve cells in the brain. They also break apart the neurotransmitter acetylcholine, which is vital for the transmission of nerve impulses.
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